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Description
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BAY 87-2243, a known inhibitor of IBa, upregulates Hmox1 in a nuclear factor manner independent of kb, thus promoting iron accumulation and inducing ferroptosis in tumor cells [129]

Why is the brain susceptible to aggregation-related diseases

Oxidative stress target and other factors: Although oxidative stress is considered as the driving force behind neurodegenerative diseases, there could be other cofounding pathological factors in humans that may not have been targeted solely by antioxidants [288,289]
