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The following day, the medium was changed to 80 l of medium supplemented with ISRIB (200 nM), ISRACT-01 (3 M) or control medium without ISRIB and ISRACT-01

Clinical trials in humans are needed to confirm efficacy and long-term safety

The mechanisms responsible for the antioxidant activity of ascorbic acid include the direct absorption of UV light (81), quenching the fluorescence of biomolecules, and controlling fluorescence-mediated bio-transformations (82)

Funding This study was supported by the Key Clinical Support Specialty of Hongkou District Health Commission of ShanghaiGeriatric Medicine (HKLCFC202412), Shanghai Hongkou District Health Committee of Medical Scientific Research Subject Major Projects (Hongwei-2301-03) and Hospital Foundation of Shanghai Fourth Peoples Hospital Affiliated to Tongji University (sykyqd06401)