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However, the increase in molar ratio is entirely explained by the fact that IGF-I and IGFBP-3 increase with the same number of moles per liter, but with a larger relative increase in IGF-I than IGFBP-3 and with IGF-II molar concentrations being unchanged (112)

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It is intended for use in clinical settings where oral administration is not feasible or where higher plasma concentrations are desired, such as in cases of severe deficiency, certain infections, or as adjunctive therapy in specific medical protocols

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The cell biology of leukocyte-mediated proteolysis

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