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Additionally, the ubiquitin-conjugating E2 enzyme variant protein 1 (Ube2v1), an E2 member of the ubiquitin-proteasome system, promotes Ubc13-mediated ubiquitination and degradation of SIRT1, thereby inhibiting H4K16 acetylation and the transcription of autophagy-related genes in colorectal cancer (76)

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The question of whether bacterial GSH-Pxs exhibit similar GSH dependence and how they influence oxidative stress tolerance and pathogenicity in bacteria remains largely unanswered