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Description
The APPswe/Ind (J20) mouse, which has two mutations in the human APP gene, was modified further to make a third mutation by replacing Met631 by leucine (M631L) in the APP gene, which corresponded to replacing Met35 of A42 with Leu
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Notably, lutein-only supplementation has shown significant improvements in MPOD and CS, whereas combined lutein and PUFA supplementation showed less pronounced effects [144]
