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Haem-loaded macrophages require the PPP for haem detoxification, probably to provide NADPH as a cofactor for haem oxygenase (HMOX)1, which metabolizes haem to biliverdin and carbon monoxide, and biliverdin reductase, which metabolizes biliverdin to bilirubin (Fig

Examples of GSH-linked defense enzymes include GSH peroxidase (GPX), GST, glutathione reductase (GRD), thioredoxins (Trx), glutaredoxin (GRX2), and PRX (Ribas et al., 2014

Thus, we start to lose that suppleness and volume of youth, and soft tissue begins to sag and wrinkle

The triad model captures the OCR data for all concentrations of doxorubicin, simulating auto-oxidation via the formation of SQ . and O 2 . intermediates, which is in good accordance with the literature 3