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While the exact regulatory mechanisms are still being determined, it is thought that 5'TOP-containing mRNA is bound by the repressive RBP Larp1, which releases the 5'TOP mRNA upon phosphorylation by mTORC1 [13, 32]

The contributors to the altered fetal growth and postnatal growth trajectory include offspring cytokine and metabolic milieu 8,9,10,11,12

10.3389/fonc.2014.00359 Front
