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Subcutaneous Cagrilintide, Semaglutide Shows Significant Weight Loss in Type 2 Diabetes Trial Kennedy Ferruggia, Associate Editor Key Takeaways The REDEFINE 2 trial showed CagriSema's superior efficacy in weight loss for individuals with obesity or overweight and type 2 diabetes, achieving a 15.7% weight loss versus 3.1% with placebo

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However, topical applications and intravenous administration are also common, each with varying effectiveness and safety profiles

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