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93,94,95,96 Advancements in carrier technology and nucleic acid modification techniques have led to significant progress in overcoming these challenges, as exemplified by the first siRNA drug, patisiran (Onpattro), which has been approved for treating hereditary transthyretin-mediated amyloidosis by degrading mRNA encoding transthyretin (TTR)

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Distinguishing these requires prospective cohort studies with pre-decline metabolite measurements and Mendelian randomization analyses using genetic variants in microbial tryptophanase as instrumental variables

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