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Description
accelerating clinical translation by establishing large animal models closer to human IDD (such as pigs and sheep), optimizing targeted delivery systems (such as responsive hydrogels) (Tang et al., 2024), and validating long-term efficacy through multicenter clinical trials (Zhang et al., 2024)

A 2006 Achilles-detachment study by Krivic and colleagues in the same journal applied BPC-157 intraperitoneally once daily at 10 g/kg, 10 ng/kg, or 10 pg/kg for 30 days in rats and reported that tendon-to-bone tissue, which did not heal spontaneously in saline controls, recovered with BPC-157 treatment, with directionally improved load-to-failure, stiffness, Young's modulus, and collagen organization at days 121, including in animals where healing had been impaired by 1 mg/kg 6-methylprednisolone though the abstract does not report numeric effect sizes or p-values

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