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They enable solubilisation levels up to 100300 times higher than in pure water, making them valuable for industrial applications, although they generally require higher surfactant concentrations [114,115]

Mechanistically, lactate accumulation, driven by PKM2, enhances Twist1-K150la, which in turn facilitates Twist1 phosphorylation, nuclear translocation, and regulation of TGFB1 transcription, thereby inducing an EndoMT-associated fibrotic phenotype in ischemic flaps