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By integrating sample information and prior knowledge, this model yields unique parameter estimates, ensuring robust and reliable results ( Statistical analysis According to the GBD database, mortality and disability rates per 100,000 population were calculated along with their 95% uncertainty intervals (UIs)

NRF2 is expressed in all cell types and its basal protein levels are usually low in unstressed conditions mainly due to KEAP1 mediated proteasomal degradation (Figure 2)

Among these reported genetic variants, 75% were noncoding with gene regulatory roles with approximately 40% being located within the enhancer regions [92]
