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Description
10.1038/s41419-018-1010-2 Cell Death Dis
TNF, LIGHT and IL-1 all trigger transcriptional and enzymatic activation of MLCK 135137 , although reports differ as to whether the transcriptional activation is mediated by nuclear factor-B, p38 mitogen-activated protein kinase (MAPK) or the transcription factor activator protein 1 (AP-1) 135,138140
The largest difference (0.97 ms) was observed in the 50mAb_50trehalose formulation
The result: a sudden, painful flare-up
