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Processes of Bone Elongation Endochondral Ossification and Growth Plate Morphology The skeleton develops by means of two different mechanisms: (1) Intramembranous ossification, involving direct differentiation of mesenchyme cells to bone as with the development of the flat bones of the skull and (2) Endochondral ossification, occurring when mesenchyme cells condense and differentiate into cartilage tissue, which then is replaced by bone forming the vertebrae, ribs and limbs [5]

injections of 10 nmol kg 1 semaglutide ( n = 6 mice and n = 3 cages), 100 nmol kg 1 GLP-1MK-801 ( n = 6 mice and n = 3 cages) or vehicle (isotonic saline, n = 6 mice and n = 3 cages) for 5 days

Therefore, Nec-1 may possess a better translational potential than Fer-1 due to its relatively well-tolerated maximum tissue concentration [195]