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Metabolic vitamin B 12 deficiency: a missed opportunity to prevent dementia and stroke Nutr Res 2016;36:109-16

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In fact, reactive oxygen species (ROS) and peroxides (H2O2) upregulate the transsulfuration pathway (homocysteine towards cysteine and eventually the GSH-Px system) and downregulate the transmethylation (homocysteine towards methionine) (Figure 3)
