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In biological samples, endogenous peroxides and other reactive species can significantly interfere with GPx activity assays, potentially leading to inaccurate results
Similarly, resistance to oxidative attack increased after overexpression of GPX5 in CHO-K1 cells, and GPX5 overexpressing cells reduced lipid peroxidation levels and downstream DNA damage marker 8-OXODG levels compared to control cells (Taylor et al., 2013)
These are among the first hypothyroidism symptoms you might notice
