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In a phase 1 safety trial, GDNF delivered directly into patients putamen (Fig

[78] demonstrated that as early as in the first trimester, women who will develop placental insufficiency showed increased arterial stiffness and higher central aortic systolic blood pressure (SBPAo) than women with normotensive pregnancies did

Additionally, introducing too many new products at once can overwhelm a healthy barrier and push it into a reactive state

12 , 16 Nose-to-Brain Delivery Efficiency of Nanoparticles Since intranasal administration can also lead to systemic drug circulation across the BBB and subsequent delivery of the drug into the brain, it is not feasible to directly measure the extent of nose-to-brain drug delivery