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The Del allele in this polymorphism is linked to a reduction in promoter activity which can result in decreased synthesis of the SOD1 enzyme, compromising the its ability to neutralize O 2 - radicals ( SOD1 gene polymorphisms extend to various diseases such as heart failure, cancer, diabetes, Downs syndrome, and amyotrophic lateral sclerosis owing to their roles in altered redox signaling

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Am Heart J 146(6):E23 Olivieri D, Marsico SA, Del Donno M (1985) Improvement of mucociliary transport in smokers by mucolytics