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Studies using HPLC data show significant increases in total thiol content after all kinds of metal exposure from different categories i.e

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Chem Commun (Camb) 2011;47:16011603

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It is possible that in addition to potential over activation of Keap 1 or lack of Keap1 turnover, Nrf2 in neutrophils is post-translationally modified in periodontitis patients, which might interfere with its ability to undergo nuclear trafficking

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