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Comprehensive cancer pre-screening represents a crucial component of patient evaluation due to the potential for these peptides to stimulate angiogenesis, which could theoretically promote malignant growth and metastasis

Using different strategies, such as xCT inhibitors (sulfasalazine or erastin) or xCT siRNA, could sensitize human gastric cancer cells to cisplatin (240)

Disease models that recapitulate pathophysiological mechanisms and phenotypes of mitochondrial and neurodevelopmental disorders remain a fundamental bottleneck in order to identify new compounds and successfully translate them to clinical practice

[DOI] [PMC free article] [PubMed] [Google Scholar] Ching W, Hang HC, Nusse R