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Description
Microbiome, Trimethylamine N-Oxide (TMAO), and cardiometabolic disease

Thus, given the potential antagonistic effects of MDMA on mesolimbic DA release, it is not surprising that MDMA coadministration has also been shown to attenuate the reinforcing effects of both cocaine (Diller et al., 2007) and METH (Clemens et al., 2006) in rats

However, no significant adverse reactions have been reported in clinical studies

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