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Authorization requires a successful The Premarket Tobacco Product Application (PMTA), which is expensive, time-consuming (typically 1224 months), and granted only in rare casesparticularly for flavored products that appeal to youth
In other words, in the physiological situation in which TARPs are present, the kinetics and pharmacology of neuronal AMPARs differ from those predicted by classical in vitro expression studies of AMPARs
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