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The Randle cycle essentially describes that when fatty acid oxidation is active there is a significant reduction in the uptake and utilization of glucose by inhibition of PDH flux, but it also works the other way around, so the production of acetyl-CoA from glycolysis will inhibit fatty acid oxidation through the generation of malonyl-CoA which can inhibit CPT I [99]

For instance, physical obstructions caused by scar tissue in the fallopian tubes inhibit effective pregnancy

doi: 10.1146/annurev-physiol-012110-142233 58 JinP.BianY.WangK.CongG.YanR.ShaY

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