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GSH depletion cause indirectly formation of endotoxins in the cytoplasm of pigmented SN cells that contribute to the degeneration of these neurons in PD Figure 2. As previously mentioned the activity of -GT is up-regulated significantly in the parkinsonian SN [61]

The therapeutic efficacy of the nanodrug-anchored platelets will be evaluated in high-cholesterol diet-fed ApoE / mouse model of atherosclerosis, which is expected to significantly mitigate oxidative damage, modulate macrophage-driven inflammatory and immune responses, and reduce the recruitment of immune cells to the plaque sites, thereby contributing to plaque regression and fostering a more stable plaque microenvironment
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