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doi: 10.1111/j.1753-4887.2005.tb00129.x, 62
A random-effects meta-analysis (k = 6) showed a negative but non-significant trend toward reduced vascular morphology markers in APOE4 versus APOE3 mice (SMD = 0.59
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Over time, an untreated leaky mitral valve puts strain on the heart and lungs, potentially causing complications such as an enlarged left atrium, atrial fibrillation (irregular heartbeat), or high blood pressure in the lung vessels ( pulmonary hypertension )
