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65 These factors occur across the lifespan and are: lower education, vision loss, high cholesterol, head injury, physical inactivity, smoking, excessive alcohol consumption, hypertension, obesity, diabetes, hearing loss, depression, infrequent social contact and air pollution

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95 The biomolecular therapies describing their effects on chronic pain in CDLBP (see Section 4) suggest that blocking proinflammatory mediators or NGF activity might hamper neuronal ingrowth into the disc