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The world population above 60 years old will cross 2 billion by the end of 2050 making almost one-fourth of the global population aged and vulnerable to multiple age-associated comorbidities (Officer et al., 2016
Collectively, this raises the notion that the observed differences here are perhaps related to long-term selenium intake, a micronutrient that has been speculated to play a role in konzo pathogenesis, due to its essential requirement for maintaining antioxidant machinery 18
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ROS can stabilize HIF-1 by inhibiting prolyl hydroxylase domain protein (PHD) activity 11
