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Moreover, compared to their separate usage, the co-treatment of exogenous GSH and Ca strengthened the GSH pool by increasing the activities of enzymes involved in GSH metabolism

In MD-treated rats, MTX progressively boosted nephrotoxicity indices and collagen disposition in kidney tissues as well as progressive additional reduction in ATP as compared with MTX-treated rats and serum carnitine levels compared with MD-treated rats

Matching tumors of relapsed versus newly diagnosed HGSOC patients also showed enhanced expression of AKR1B1, ITGAV, TGF1 and G6PD protein in relapsed tumors