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doi: 10.1007/s00702-020-02266-z [DOI] [PMC free article] [PubMed] [Google Scholar] 2.Zargaran D, Zoller F, Zargaran A, et al
Aziz M, Brenner M, Wang P

While both amino acid replacements have side chains that are polar as opposed to the original glycine, aspartic acid also introduces a negative charge to the surrounding, as well as being larger than serine
However, both peptides distribute systemically and show time-independent efficacy neither requires circadian optimization