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A balance is needed because, at high doses of 500-600 mg, caffeine can increase heart rate and shivering[9 Trusted Source 2015 - Current neuropharmacology Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug

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ECs exhibited alterations in their morphology, with accelerated proliferation ( The analysis of the proteome of ECs grown under uremic conditions versus control ( Therefore, endothelial activation is associated with inflammation, oxidative stress, and alterations of immune mechanisms in CKD patients