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Description
In the one-carbon metabolism domain, common variants like MTHFR C677T can elevate homocysteine and lower folate availability to the brain
Tsujimoto, Y
Steric Hindrance Structural steric hindrance diminishes target accessibility and hence raises the transition state energy of the interacting species
A major mechanism includes hypophosphorylation of eIF4E-binding protein 1 (4E-BP1), which elicits ET inhibition with minimal effect on CT 38
