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Dysfunction of these cells contributes to chronic inflammatory and autoimmune diseases such as gout, rheumatoid arthritis (RA), osteoarthritis (OA), cryopyrin-associated periodic syndromes (CAPS), inflammatory bowel disease, and neurodegeneration

doi: 10.14309/01.ajg.0000713129.5640956 Dileep N Lobo, Luca Gianotti, Alfred Adiamah, Rocco Barazzoni, Nicolaas E P Deutz, Ketan Dhatariya, Paul L Greenhaff, Michael Hiesmayr, Dorthe Hjort Jakobsen, Stanislaw Klek, Zeljko Krznaric, Olle Ljungqvist, Donald C McMillan, Katie E Rollins, Marina Panisic Sekeljic, Richard J E Skipworth, Zeno Stanga, Audrey Stockley, Ralph Stockley, Arved Weimann

BSL, DB, and XG synthesized and purified all heavy isotopelabeled compounds used in the studies