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Diem SJ, Greer NL, MacDonald R, et al
Thymoquinones propensity to help maintain a normal inflammatory response in the GI tract includes down-regulating inflammatory cascade enzymes, as well as certain inflammatory cytokines, tumor necrosis factor-alpha, and C-reactive protein
doi: 10.1038/nature11400 81 PallavKDowdSEVillafuerteJYangXKabbaniTHansenJet al
So far these cutoffs for 4cB12 have been validated against hemoglobin concentrations and cognitive status (based on the Mini Mental State Examination), although additional validation studies using other cognitive and neurological outcomes are needed
