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Moreover, sustained elevation of CORT can induce the upregulation of pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNF-), enhance microglial activation, disrupt bloodbrain barrier (BBB) integrity, and facilitate the infiltration of peripheral immune cells into the central nervous system (CNS), thereby exacerbating neuroinflammation (Hooper et al., 2018)
Additionally, the elderly population may have decreased absorption or utilization of dietary vitamin B6, making supplementation a viable option
This study confirms the reliability and efficiency of the rmTBI model in assessing TBI [155]
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