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Megaloblastic anemia in these patients may not appear until a long period after the total gastrectomy (510 y), because of the capacity of the body to reutilize the vitamin
One carbon metabolism and epigenetics: understanding the specificity
Additionally, changes in the microenvironment, such as redox state, altered pH, and the presence of reactive oxygen species (ROS) at the pathophysiological sites, can act as sensitive stimuli to trigger drug release in those areas

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