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Based on reported side effects, Melanotan 1 has the narrower, milder profile because it targets a single receptor
While MT2 upregulates the melanogenesis pathway, melanosome transfer from melanocytes to keratinocytes requires UV-induced oxidative stress signaling
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Int J Dev Neurosci 31:2124 Ribas GS, Manfredini V, de Mari JF, Wayhs CY, Vanzin CS, Biancini GB, Sitta A, Deon M, Wajner M, Vargas CR (2010) Reduction of lipid and protein damage in patients with disorders of propionate metabolism under treatment: a possible protective role of l-carnitine supplementation