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Both molecules of PfTrx-2 are in reduced form with distances between S atoms of Cys 82 and Cys 85 of 3.7 and 3.9 for A and B chains respectively ( Fig

It blocks the synthesis of DNA, mRNA, and protein synthesis by interacting with purine bases on gDNA or mitochondrial DNA, inhibiting DNA replication and promoting cell apoptosis ( A previous study has found that QUE enhanced the growth inhibition of CIS in HepG2 HCC cells by up-regulating p16 expression ( As an effective chemotherapeutic agent, CIS is used to treat various human cancers

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