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Targeting HIF-1 translation PI3K inhibition Buparlisib (BKM120) As the most clinically advanced agent of all PI3K-inhibiting medicines, Buparlisib is a potent, selective, orally bioavailable class I pan-PI3K inhibitor with properties against p110-, -, -, and - enzymes at IC 50 values of 52 M, 166 M, 116 M, and 262 M, respectively [247]
[9] Welbourne, T.C
Kantarjian HM, Begna KH, Altman JK, Goldberg SL, Sekeres MA, Strickland SA, et al
Wei D, Chen D, Mou H, Chakraborty S, Wei B, Tan L, et al
