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Dogs at this stage may exhibit pronounced jaundice, severe vomiting, and diarrhea, causing dehydration and electrolyte imbalances

Although Lopinavir exhibits some antiviral activity, its association with hepatotoxicity must also be considered

CD44, as a hyaluronic acid receptor highly expressed on CRC stem cells, enables hyaluronic acid-based nanocarriers to effectively penetrate the tumor extracellular matrix and eliminate cancer stem cells, reducing recurrence risk ( Collectively, these systems face challenges including TME heterogeneity, immune clearance, and scalability