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PA, in particular, acts as a major opportunistic pathogen that may exacerbate CF-related pulmonary pathologies by interfering with ferroptosis regulatory mechanismsthus worsening lung injury (this aspect is addressed in the Pediatric Respiratory Infections section) (Dar et al

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80 , 81 Activated neutrophils release additional cytokines and chemokines, which exacerbate the inflammatory response, creating a vicious cycle of tissue damage

Cyclosporine, a calcineurin inhibitor that suppresses the immune system, is also used to treat plaque psoriasis