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Biology of the TAM receptors

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26 and the references therein), they have limitations associated with well-known multiple adverse reactions, genotoxicity, and special requirements for storage, handling, and administration, posing challenges with respect to the standard operating procedure (SOP) for MDA campaigns requiring single or double dose activity, oral administration, minimal toxicity, and stability in tropical settings 27

Additional early symptoms include follicular hyperkeratosis, increased susceptibility to infection and cancer and anemia equivalent to iron deficient anemia