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Description
Glutathione reductase (GR) is a flavoprotein enzyme that converts oxidized glutathione (GSSG) to reduced glutathione (GSH) via the oxidation of NADPH to NADP + whereas glutathione peroxidase is a free radical and hydrogen peroxide elimination enzyme that catalyzes glutathione oxidation in the presence of a hydroperoxide

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Although the pKa value of Cys-thiol GSH is relatively high (8.99.4) [3], indicating low reactivity in the intracellular environment, its central role in protecting cells from reactive oxygen/nitrogen species (RONS) is based on enzyme-catalyzed reactions, efficient recycling pathways, as well as the mass effect achieved by its high intracellular concentrations (210 mM)
In 1963, Italian scientists reported the extraction of a phenylethanoid glycoside from mullein ( Verbascum sinuatum L
