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Nitric Oxide Synthesis and Function Vasodilators, such as acetylcholine, bradykinin, and adenosine do not exert their effects upon the vascular smooth muscle cells in the absence of the overlying endothelium

AUC is the area under the plasma drug concentration-time curve

They also achieve higher blood concentrations than typically possible with oral supplements

Cascone T, Sepesi B, Lin H, Kalhor N, Parra ER, Jiang M, Godoy MCB, Zhang J, Fossella F, Tsao AS, Lam VK, Lu C, Mott FE, Simon GR, Antonoff MB, Reza MJ, Rice D, Behren C, Weissferdt A, Moran C, Vaporciyan AA, Lee JJ, Swisher SG, Gibbons DL, Wistuba II, William WN, Heymach JV