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Beyond molecular and functional analyses, biochemical assays confirmed that GpoA presents GSH-dependent activity analogous to that observed in eukaryotic glutathione peroxidases [12]

These include reduced expression of cereblon, or other proteins involved in the UPS, genetic alterations including mutations, deletions or alternative splice variants, and upregulation of drug efflux pump(s)

Despite the existence of several therapeutic modalities, namely psychotherapy and antidepressants, there are several problems associated with the therapy of this disease, such as the development of resistance and relapses after the end of therapy

This paper delves into the complexities of Humanin, uncovering its multifaceted nature and potential clinical applications