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For most of the carcinogenic NAs, the established mechanisms of action involve metabolic activation primarily via cytochrome 450 enzymes (CYPs), and mainly through -hydroxylation, generating highly reactive, electrophilic intermediates, which can ultimately form covalent DNA adducts

However, they are caused by the acid going back up into the oesophagus, rather than the change in cells in the oesophagus.

I want them to be where it's almost like you can't even tell that it's from one of my books, just a totally different culture taking the tropes of it and turning it into something new