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Systematic reviews and numerous original studies have tightly integrated GPX4 into the complex pathogenic network of OA and clearly pointed out the potential and significant therapeutic value of targeting the GPX4 and ferroptosis axis

Oral supplements can work for: Dietary deficiencies (e.g., in vegans), mild absorption issues, or as a maintenance option after initial injection therapy

Copper-regulated kinases (e.g., ULK1, ULK2, and MEK1) and the cAMP-degrading enzyme PDE3B mediate copper-dependent signaling that influences autophagosome formation, cell proliferation, and metabolism (54)