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As a replacement strategy, lithium orotate (LiO), reported to bind A less avidly than lithium carbonate, raised parenchymal Li, reduced A and phospho-tau, and improved synaptic/myelin markers and behavior at physiological Li levels in AD mice, though these salt-specific advantages and translational implications remain preclinical [2123]

These rhythms are controlled by the suprachiasmatic nucleus (SCN) located in the hypothalamus, which tracks signals the SCN receives from the external environment (light)