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This section focuses on disease-modifying strategies based on non-dopaminergic mechanisms, encompassing multiple directions such as regulation of protein homeostasis, restoration of brain iron metabolism balance, suppression of neuroinflammation, and improvement of energy metabolism

The activation of the NLRP3 inflammasome is thought to seed and spread the A pathology within and between brain structures (Venegas et al., 2017)

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Some individuals may also consume fewer foods naturally rich in B12, especially if their diet changes significantly