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The tissue becomes stiff, brittle, and prone to flare cycles

519 Specifically, high blood glucose-induced insulin resistance in CRC cells leads to increased BMP4 expression, which activates the BMP4-Smad1/5/8 signaling pathway

The off-period prevents receptor downregulation and maintains responsiveness

C-myc overexpression promotes oral cancer cell proliferation and migration by enhancing glutaminase and glutamine synthetase activity
