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However, improved CPT1A activity or NAD + -mediated SIRT activation may contribute to reducing oxidative stress and fatty acid accumulation by -oxidation stimulation

Additionally, cancer cells often rely on glutaminolysis to support their metabolic needs

These changes were reversed by both wild-type BRCA1 and NAC treatment

Autophagic cell death, characterized with upregulation of Beclin 1 and elevated LC3 cleavage, is also induced by ISA in ovarian cancer cells, which was found to be associated with PEA-15 upregulation and following ERK activation (Weng et al., 2016)